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Concerns

Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs)

Nonnucleoside reverse transcriptase inhibitors (NNRTIs)

Protease inhibitors

Multi-class combinations

Fusion inhibitors

Entry inhibitors, CCR5 antagonist

HIV integrase strand transfer inhibitors

Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs)

 

 

 

 

Trade name (Generic)
Abbreviation
Drug interactions and
precautions
Oral health care concerns
Combivir (zidovudine and lamivudine) ZDV and 3TC See Retrovir See Retrovir and Epivir
Emtriva (emtricitabine) FTC n/a Hyperpigmenation
Epivir (lamivudine) 3TC n/a Neutropenia, thrombocytopenia
Epzicom (abacavir and lamivudine) ABC and 3TC n/a See Epivir and Ziagen
Retrovir (zidovudine) ZDV or AZT Coadministration with clarithromycin enhances myelosuppressive effect and decreases zidovudine concentration; fluconazole may decrease the metabolism of zidovudine Anemia, neutropenia, oral mucosal pigmentation, taste perversion, dysphagia, oral ulcers
Trizivir (abacavir and zidovudine and lamivudine) ABC and ZDV and 3TC See Retrovir See Retrovir, Epivir ansd Ziagen
Truvada (emtricitabine and tenofovir DS) FTC and TDF See Viread See Emtriva and Viread
Videx (didanosine:buffered version);Videx-EC (didanosine: delayed-release capsule) ddI Nonenteric coated didanosine may decrease the absorption of azole antifungals Xerostomia, peripheral neuropathy
Viread (tenofovir) TDF Avoid acyclovir and valacyclovir that decrease excretion of tenofovir n/a
Zerit (stavudine) d4T n/a Peripheral neuropathy,
exacerbates bone marrow suppression
Ziagen(abacavir) ABC n/a Oral ulceration, erythema multiforme, paresthesias

Nonnucleoside reverse transcriptase inhibitors (NNRTIs)

 

 

 

 

Trade name (Generic)
Abbreviation
Drug interactions and
precautions
Oral health care concerns
Edurant (rilpivirine) RPV  Avoid dexamethasone that decreases rilpivirine effect
and decrease dexamethasone effect; concomitant use with ketoconazole, fluconazole, or itraconazole reduces azole concentration and elevates rilpivirine concentration;
avoid erythromycin and clarithromycin
n/a
Intelence (etravirine) ETV May decrease serum concentration of itraconazole and
ketoconazole, may increase
serum concentration of
voriconazole, decreases
serum concentration of clarithromycin
May cause cushingoid appearance, erythema multiforme, anemia, paresthesias, stomatitis, xerostomia
Rescriptor (delaviridine)  DLV May increase serum concentration of fentanyl, may diminish therapeutic effect of tramadol May cause cushingoid appearance, erythema multiforme, anemia, thrombocytopenia, pancytopenia, mouth ulcers, gum hemorrhage
Sustiva (efavirenz)  EFV Benzodiazepine precaution, may increase serum concentration of fentanyl, decreased concentration of itraconazole and voriconazole, voriconazole may increase efavirenz concentration May cause cushingoid appearance, abnormal taste, erythema multiforme, paresthesias, neutropenia
Viramune (nevirapine, immediate realese)
Viramune XR (nevirapine, extended release)
NVP Decreased concentration of voriconazole, voriconazole may increase nevirapine concentration Oral ulceration, erythema multiforme

Protease inhibitors

 

 

 

 

Trade name (Generic)
Abbreviation
Drug interactions and
precautions
 Oral health care concerns
Aptivus (tipranavir) TPV Benzodiazepine precaution, azole antifungal precaution, macrolide antibiotic precaution Increased bleeding in
hemophiliacs, may impair
platelet aggregation and
increase bleeding
risk
Crixivan(indinavir) IDV Benzodiazepine precaution, azole antifungal precaution, macrolide antibiotic precaution, may increase concentration of fentanyl Increased bleeding in hemophiliacs, anemia
Invirase (saquinavir) SQV Benzodiazepine precaution, azole antifungal precaution, macrolide antibiotic precaution Increased bleeding in hemophiliacs, taste alteration, oral
ulceration, dysphagia,
neutropenia, thrombocytopenia,
anemia
Kaletra (lopinavir and ritonavir) LPV and RTV See Norvir and benzodiazepine precaution; increases levels of clarithromycin, ketoconazole, and itraconazole; decreases
level of voriconazole; diminishes therapeutic effect of tramadol; metronidazole may interact with alcohol in Kaletra oral solution
See Norvir and increased bleeding in hemophiliacs, neutropenia, ulcerative stomatitis, xerostomia, facial edema
Lexiva (fosamprenavir) FOS-APV Benzodiazepine precaution, azole antifungal precaution, macrolide antibiotic precaution, may enhance the toxic effect of meperidine Increased bleeding in hemophiliacs, cushingoid appearance, erythema multiforme, neutropenia, hemolytic anemia
Norvir (ritonavir) RTV Benzodiazepine precaution, avoid meperidine, propoxyphene, piroxicam; ketoconazole increases ritonavir levels; clarithromycin and erythromycin reduce ritonavir levels; ritonavir may increase levels of prednisone; metronidazole may enhance adverse effects of ritonavir Increased bleeding in hemophiliacs, may cause cushingoid appearance, paresthesias, taste perversion, parotid lipomatosis
Prezista (darunavir) DRV Benzodiazepine precaution, azole antifungal precaution, macrolide antibiotic precaution, darunavir may increase the serum concentration of topical lidocaine, may enhance the toxic effect of meperidine  Increased bleeding in hemophiliacs, may cause cushingoid appearance, erythema multiforme, oral lesions, facial edema, osteonecrosis, pancytopenia, paresthesias, xerostomia
Reyataz (atazanavir) ATV Benzodiazepine precaution, azole antifungal precaution, macrolide antibiotic precaution, increases serum concentration of fentanyl, may enhance the toxic effect of meperidine Increased bleeding in hemophiliacs, may cause cushingoid appearance, erythema multiforme, neutropenia, anemia, thrombocytopenia
Viracept (nelfinavir) NFV Benzodiazepine precaution, azole antifungal precaution, macrolide antibiotic precaution, increases the serum concentration of fentanyl, may enhance the toxic effect of meperidine Increased bleeding in hemophiliacs, may cause cushingoid appearance, neutropenia, thrombocytopenia, anemia, paresthesias, mouth ulcers

Multi-class combinations

 

 

 

 

Trade name (Generic)
Abbreviation
Drug interactions and
precautions
Oral health care concerns
Atripla (efavirenz, emtricitabine and tenofovir) EFV/FTC/TDF See Sustiva, Emtriva and Viread See Sustiva, Emtriva and Viread
Complera (emtricitabine, rilpivirine and tenofovir) FTC/RPV/TDF See Truvada and Edurant See Truvada and Edurant
Stribild (elvitegravir, cobicistat, emtricitabine and tenofovir) EVG/COBI/FTC/TDF; QUAD See Truvada and benzodiazepine precaution See Truvada

Fusion inhibitors

 

 

 

 

Trade name (Generic)
Abbreviation
Drug interactions and
precautions
Oral health care concerns
Fuzeon (enfuvirtide) ENF or T20  n/a Neutropenia, thrombocytopenia, xerostomia, taste disturbance

 Entry inhibitors, CCR5 antagonist

 

 

 

 

Trade name (Generic)
Abbreviation
Drug interactions and
precautions
Oral health care concerns
Selzentry (maraviroc) MVC Avoid ketoconazole, itraconazole, clarithromycin Neutropenia, anemia, herpes exacerbation, stomatitis, osteonecrosis

 HIV integrase strand transfer inhibitors

 

 

 

 

Generic name
Abbreviation
Drug interactions and
precautions
Oral health care concerns
Isentress (raltegavir) RAL  n/a Neutropenia, thrombocytopenia, facial wasting
Tivicay (dolutegravir) DTG  n/a Neutropenia

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